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EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications

EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along with other PRC2 components mediates gene expression suppression via the methylation of Histone H3 at lysine 27. Recent studies have revealed a dichotomous role of EZH2 in physiology and in the pathogenesis of canc...

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Detalles Bibliográficos
Autores principales: Li, Boheng, Chng, Wee-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868783/
https://www.ncbi.nlm.nih.gov/pubmed/31752930
http://dx.doi.org/10.1186/s13045-019-0814-6