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EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications
EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along with other PRC2 components mediates gene expression suppression via the methylation of Histone H3 at lysine 27. Recent studies have revealed a dichotomous role of EZH2 in physiology and in the pathogenesis of canc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868783/ https://www.ncbi.nlm.nih.gov/pubmed/31752930 http://dx.doi.org/10.1186/s13045-019-0814-6 |