Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity

[Image: see text] Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized. The cyclic monomer showed an increased activity in vitro against Candida albicans and Candida parapsilosis, compared to Cm-p5. Initially, 14...

Descripción completa

Detalles Bibliográficos
Autores principales: Vicente, Fidel E. Morales, González-Garcia, Melaine, Diaz Pico, Erbio, Moreno-Castillo, Elena, Garay, Hilda E., Rosi, Pablo E., Jimenez, Asiel Mena, Campos-Delgado, Jose A., Rivera, Daniel G., Chinea, Glay, Pietro, Rosemeire C. L. R., Stenger, Steffen, Spellerberg, Barbara, Kubiczek, Dennis, Bodenberger, Nicholas, Dietz, Steffen, Rosenau, Frank, Paixão, Márcio Weber, Ständker, Ludger, Otero-González, Anselmo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868880/
https://www.ncbi.nlm.nih.gov/pubmed/31763531
http://dx.doi.org/10.1021/acsomega.9b02201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868880/
https://www.ncbi.nlm.nih.gov/pubmed/31763531
http://dx.doi.org/10.1021/acsomega.9b02201

Ejemplares similares