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Nickel-Catalyzed Amidoalkylation Reaction of γ-Hydroxy Lactams: An Access to 3-Substituted Isoindolinones†

[Image: see text] An efficient Ni(ClO(4))(2)·6H(2)O-promoted amidoalkylation reaction for the synthesis of 3-substituted isoindolinones involving various γ-hydroxy lactams and nucleophiles has been successfully developed. The transformation proceeds with both carbon (ketones and arenes) and heteroat...

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Detalles Bibliográficos
Autores principales: Zhang, Shuo, Shi, Xinhua, Li, Jichao, Hou, Zitong, Song, Zihe, Su, Xiaofeng, Peng, Dan, Wang, Feng, Yu, Yitao, Zhao, Guilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868882/
https://www.ncbi.nlm.nih.gov/pubmed/31763566
http://dx.doi.org/10.1021/acsomega.9b02853
Descripción
Sumario:[Image: see text] An efficient Ni(ClO(4))(2)·6H(2)O-promoted amidoalkylation reaction for the synthesis of 3-substituted isoindolinones involving various γ-hydroxy lactams and nucleophiles has been successfully developed. The transformation proceeds with both carbon (ketones and arenes) and heteroatom (alcohols, thiols, and amines) nucleophiles and in both intermolecular and intramolecular manners. The prominent features of the present strategy are wide substrate scope, excellent group tolerability, and moderate to good yields (up to 96% yield). The present strategy is also characterized by remarkable superiority over the current synthetic methods. Furthermore, the reaction could be scaled up to the multigram scale.