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Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies

[Image: see text] The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of co...

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Detalles Bibliográficos
Autores principales: Lim, Andrew S. T., Vincent, Isabel M., Barrett, Michael P., Gilbert, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869403/
https://www.ncbi.nlm.nih.gov/pubmed/31763544
http://dx.doi.org/10.1021/acsomega.9b02507