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Isolation of senescent cells by iodixanol (OptiPrep) density gradient‐based separation

OBJECTIVES: Chemotherapeutic drugs induce senescence in cancer cells but, unlike replicative senescence or oncogene‐induced senescence, do so rather inefficiently and depending on DNA damage. A thorough understanding of the biology of chemotherapy‐induced senescent cells requires their isolation fro...

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Detalles Bibliográficos
Autores principales: Kovacovicova, Kristina, Vinciguerra, Manlio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869531/
https://www.ncbi.nlm.nih.gov/pubmed/31517418
http://dx.doi.org/10.1111/cpr.12674