Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling

Opioids are powerful addictive agents that alter dopaminergic influence on reward signaling in medium spiny neurons (MSNs) of the nucleus accumbens. Repeated opioid exposure triggers adaptive changes, shifting reward valuation to the allostatic state underlying tolerance. However, the cellular subst...

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Detalles Bibliográficos
Autores principales: Muntean, Brian S., Dao, Maria T., Martemyanov, Kirill A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871051/
https://www.ncbi.nlm.nih.gov/pubmed/31644915
http://dx.doi.org/10.1016/j.celrep.2019.09.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871051/
https://www.ncbi.nlm.nih.gov/pubmed/31644915
http://dx.doi.org/10.1016/j.celrep.2019.09.034

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