Cargando…
APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
Rabbits with naturally high levels of cholesterol ester transfer protein (CETP), unlike rodents, have become an interesting animal model for the study of lipid metabolism and atherosclerosis, as they have similarities to humans in lipid metabolism, cardiovascular physiology and susceptibility to dev...
Autores principales: | Beierfuß, Anja, Hunjadi, Monika, Ritsch, Andreas, Kremser, Christian, Thomé, Claudius, Mern, Demissew Shenegelegn |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871866/ https://www.ncbi.nlm.nih.gov/pubmed/31751427 http://dx.doi.org/10.1371/journal.pone.0225527 |
Ejemplares similares
-
Knockout of Apolipoprotein E in rabbit promotes premature intervertebral disc degeneration: A new in vivo model for therapeutic approaches of spinal disc disorders
por: Beierfuß, Anja, et al.
Publicado: (2017) -
Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders
por: Shenegelegn Mern, Demissew, et al.
Publicado: (2017) -
Identification and characterization of human nucleus pulposus cell specific serotypes of adeno-associated virus for gene therapeutic approaches of intervertebral disc disorders
por: Mern, Demissew S., et al.
Publicado: (2015) -
A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches
por: Mern, Demissew S., et al.
Publicado: (2013) -
Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic Treatments of Cervical Disc Diseases
por: Mern, Demissew S., et al.
Publicado: (2014)