Atomistic simulations shed new light on the activation mechanisms of RORγ and classify it as Type III nuclear hormone receptor regarding ligand-binding paths

The molecular recognition of the RORγ nuclear hormone receptor (NHR) ligand-binding domain (LBD) has been extensively studied with numerous X-ray crystal structures. However, the picture afforded by these complexes is static and does not fully explain the functional behavior of the LBD. In particula...

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Detalles Bibliográficos
Autores principales: Saen-Oon, Suwipa, Lozoya, Estrella, Segarra, Victor, Guallar, Victor, Soliva, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872664/
https://www.ncbi.nlm.nih.gov/pubmed/31754232
http://dx.doi.org/10.1038/s41598-019-52319-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872664/
https://www.ncbi.nlm.nih.gov/pubmed/31754232
http://dx.doi.org/10.1038/s41598-019-52319-x

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