HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1

Temozolomide (TMZ) is an alkylating agent chemotherapy drug used as a first-line treatment for glioblastoma multiforme (GBM). O(6)-methyl-guanine DNA methyltransferase (MGMT) repairs DNA damage induced by TMZ; hence, elevated MGMT levels usually correlate with TMZ resistance. MGMT promoter methylati...

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Detalles Bibliográficos
Autores principales: Santos-Barriopedro, Irene, Li, Yixuan, Bahl, Sonali, Seto, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872666/
https://www.ncbi.nlm.nih.gov/pubmed/31798765
http://dx.doi.org/10.18632/genesandcancer.197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872666/
https://www.ncbi.nlm.nih.gov/pubmed/31798765
http://dx.doi.org/10.18632/genesandcancer.197

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