Potential for imaging the high-affinity state of the 5-HT(1B) receptor: a comparison of three PET radioligands with differing intrinsic activity

BACKGROUND: Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT(1B) receptors. The 5-HT(1B) receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competit...

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Detalles Bibliográficos
Autores principales: Lindberg, Anton, Arakawa, Ryosuke, Nogami, Tsuyoshi, Nag, Sangram, Schou, Magnus, Elmore, Charles S., Farde, Lars, Pike, Victor W., Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872687/
https://www.ncbi.nlm.nih.gov/pubmed/31754940
http://dx.doi.org/10.1186/s13550-019-0570-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872687/
https://www.ncbi.nlm.nih.gov/pubmed/31754940
http://dx.doi.org/10.1186/s13550-019-0570-1

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