Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist

OBJECTIVE: To identify an agonist of RXRα and RARα with reduced undesired profiles of all-trans retinoic acid for differentiation-inducing therapy of acute promyelocytic leukemia (APL), such as its susceptibility to P450 enzyme, induction of P450 enzyme, increased sequestration by cellular retinoic...

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Detalles Bibliográficos
Autores principales: Koshiishi, Chie, Kanazawa, Takanori, Vangrevelinghe, Eric, Honda, Toshiyuki, Hatakeyama, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872757/
https://www.ncbi.nlm.nih.gov/pubmed/31768440
http://dx.doi.org/10.1016/j.heliyon.2019.e02849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872757/
https://www.ncbi.nlm.nih.gov/pubmed/31768440
http://dx.doi.org/10.1016/j.heliyon.2019.e02849

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