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Discovery of novel helix binding sites at protein-protein interfaces

Protein-protein interactions (PPIs) play a key role in numerous biological processes. Many efforts have been undertaken to develop PPI modulators for therapeutic applications; however, to date, most of the peptide binders designed to target PPIs are derived from native binding helices or using the n...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Sun, Xiangyu, Zhang, Changsheng, Lai, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872852/
https://www.ncbi.nlm.nih.gov/pubmed/31768230
http://dx.doi.org/10.1016/j.csbj.2019.11.001