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Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease

Neurodegenerative disorders progress across the brain in characteristic spatio-temporal patterns. A better understanding of the factors underlying the specific cell and tissue vulnerability responsible for such patterns could help identify the molecular origins of these conditions. To investigate th...

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Detalles Bibliográficos
Autores principales: Freer, Rosie, Sormanni, Pietro, Ciryam, Prajwal, Rammner, Burkhard, Rizzoli, Silvio O., Dobson, Christopher M., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872855/
https://www.ncbi.nlm.nih.gov/pubmed/31768427
http://dx.doi.org/10.1016/j.heliyon.2019.e02589