Cargando…

MUC1-C REPRESSES THE RASSF1A TUMOR SUPPRESSOR IN HUMAN CARCINOMA CELLS

RASSF1A encodes a tumor suppressor that inhibits the RAS→RAF→MEK→ERK pathway and is one of the most frequently inactivated genes in human cancers. MUC1-C is an oncogenic effector of the cancer cell epigenome that is overexpressed in diverse carcinomas. We show here that MUC1-C represses RASSF1A expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajabi, Hasan, Hata, Tsuyoshi, Li, Wei, Long, Mark D, Hu, Qiang, Liu, Song, Raina, Deepak, Kui, Ling, Hong, Deli, Samur, Mehmet, Kufe, Donald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872931/ https://www.ncbi.nlm.nih.gov/pubmed/31435022 http://dx.doi.org/10.1038/s41388-019-0940-1

Ejemplares similares

Correction: MUC1-C represses the RASSF1A tumor suppressor in human carcinoma cells
por: Rajabi, Hasan, et al.
Publicado: (2019)

MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia
por: Tagde, Ashujit, et al.
Publicado: (2016)

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
por: Yasumizu, Yota, et al.
Publicado: (2020)

MUC1-C INTEGRATES PD-L1 INDUCTION WITH REPRESSION OF IMMUNE EFFECTORS IN NON-SMALL CELL LUNG CANCER
por: Bouillez, Audrey, et al.
Publicado: (2017)

Author Correction: MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
por: Yasumizu, Yota, et al.
Publicado: (2020)

MUC1-C drives DNA methylation in cancer
por: Rajabi, Hasan, et al.
Publicado: (2016)

Targeting MUC1-C suppresses polycomb repressive complex 1 in multiple myeloma
por: Tagde, Ashujit, et al.
Publicado: (2017)

MUC1-C activates EZH2 expression and function in human cancer cells
por: Rajabi, Hasan, et al.
Publicado: (2017)

RASSF6; the Putative Tumor Suppressor of the RASSF Family
por: Iwasa, Hiroaki, et al.
Publicado: (2015)

MUC1-C ACTIVATES THE TAK1 INFLAMMATORY PATHWAY IN COLON CANCER
por: Takahashi, Hidekazu, et al.
Publicado: (2015)

TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS
por: Raina, Deepak, et al.
Publicado: (2013)

Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells
por: Alam, Maroof, et al.
Publicado: (2014)

TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN
por: Jin, Caining, et al.
Publicado: (2012)

COOPERATIVITY OF THE MUC1 ONCOPROTEIN AND STAT1 PATHWAY IN POOR PROGNOSIS HUMAN BREAST CANCER
por: Khodarev, Nikolai, et al.
Publicado: (2009)

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells
por: Kharbanda, Akriti, et al.
Publicado: (2014)

DNA METHYLATION BY DNMT1 AND DNMT3b METHYLTRANSFERASES IS DRIVEN BY THE MUC1-C ONCOPROTEIN IN HUMAN CARCINOMA CELLS
por: Rajabi, Hasan, et al.
Publicado: (2016)

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target
por: Raina, Deepak, et al.
Publicado: (2015)

Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia
por: Kufe, Donald W.
Publicado: (2022)

Dependence on MUC1-C in Progression of Neuroendocrine Prostate Cancer
por: Kufe, Donald
Publicado: (2023)

MUC1-C ACTIVATES BMI1 IN HUMAN CANCER CELLS
por: Hiraki, Masayuki, et al.
Publicado: (2016)

Cooperative Interaction between the MUC1-C Oncoprotein and the Rab31 GTPase in Estrogen Receptor-Positive Breast Cancer Cells
por: Jin, Caining, et al.
Publicado: (2012)

MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer
por: Yamashita, Nami, et al.
Publicado: (2021)

Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer
por: Hiraki, Masayuki, et al.
Publicado: (2018)

MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells
por: Hagiwara, Masayuki, et al.
Publicado: (2021)

Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer
por: Yamashita, Nami, et al.
Publicado: (2022)

Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells
por: Kufe, Donald W.
Publicado: (2022)

KIBRA attains oncogenic activity by repressing RASSF1A
por: , Anuj, et al.
Publicado: (2017)

MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells
por: Bhattacharya, Atrayee, et al.
Publicado: (2022)

Addiction of Cancer Stem Cells to MUC1-C in Triple-Negative Breast Cancer Progression
por: Yamashita, Nami, et al.
Publicado: (2022)

The SARAH Domain of RASSF1A and Its Tumor Suppressor Function
por: Dittfeld, Claudia, et al.
Publicado: (2012)

MUC1‐C drives myeloid leukaemogenesis and resistance to treatment by a survivin‐mediated mechanism
por: Stroopinsky, Dina, et al.
Publicado: (2018)

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
por: Hasegawa, Masanori, et al.
Publicado: (2016)

Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non–neuroendocrine Small Cell Lung Cancer
por: Fushimi, Atsushi, et al.
Publicado: (2022)

Tumor Suppressor RASSF1A Promoter: p53 Binding and Methylation
por: Tian, Yihao, et al.
Publicado: (2011)

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation
por: Li, Wenjiao, et al.
Publicado: (2018)

RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy
por: García-Gutiérrez, Lucía, et al.
Publicado: (2020)

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis
por: Reeves, Mark E., et al.
Publicado: (2013)

Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment
por: Morimoto, Yoshihiro, et al.
Publicado: (2022)

MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer
por: Yamashita, Nami, et al.
Publicado: (2023)

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
por: Hesson, Luke B, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_beq1adjg3qal40ka773bn3d7ov