MUC1-C REPRESSES THE RASSF1A TUMOR SUPPRESSOR IN HUMAN CARCINOMA CELLS

RASSF1A encodes a tumor suppressor that inhibits the RAS→RAF→MEK→ERK pathway and is one of the most frequently inactivated genes in human cancers. MUC1-C is an oncogenic effector of the cancer cell epigenome that is overexpressed in diverse carcinomas. We show here that MUC1-C represses RASSF1A expr...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajabi, Hasan, Hata, Tsuyoshi, Li, Wei, Long, Mark D, Hu, Qiang, Liu, Song, Raina, Deepak, Kui, Ling, Hong, Deli, Samur, Mehmet, Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872931/
https://www.ncbi.nlm.nih.gov/pubmed/31435022
http://dx.doi.org/10.1038/s41388-019-0940-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872931/
https://www.ncbi.nlm.nih.gov/pubmed/31435022
http://dx.doi.org/10.1038/s41388-019-0940-1

Ejemplares similares