CRISPRa-mediated FOXP3 gene upregulation in mammalian cells

BACKGROUND: Forkhead box P3(+) (FOXP3(+)) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans results in loss of differentiation potential into Treg cells and are responsi...

Descripción completa

Detalles Bibliográficos
Autores principales: Forstnerič, Vida, Oven, Irena, Ogorevc, Jernej, Lainšček, Duško, Praznik, Arne, Lebar, Tina, Jerala, Roman, Horvat, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873431/
https://www.ncbi.nlm.nih.gov/pubmed/31832140
http://dx.doi.org/10.1186/s13578-019-0357-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873431/
https://www.ncbi.nlm.nih.gov/pubmed/31832140
http://dx.doi.org/10.1186/s13578-019-0357-0

Ejemplares similares