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CRISPRa-mediated FOXP3 gene upregulation in mammalian cells
BACKGROUND: Forkhead box P3(+) (FOXP3(+)) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans results in loss of differentiation potential into Treg cells and are responsi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873431/ https://www.ncbi.nlm.nih.gov/pubmed/31832140 http://dx.doi.org/10.1186/s13578-019-0357-0 |