Cargando…

Study protocol: design and rationale for an exploratory phase II randomized controlled trial to determine optimal vitamin D(3) supplementation strategies for acute fracture healing

BACKGROUND: Observational studies have found that 75% of healthy adult fracture patients (ages 18–50) have serum 25-hydroxyvitamin D (25(OH)D) levels < 30 ng/mL. Although lower serum 25(OH)D levels have yet to be correlated to fracture healing complications or poor fracture outcomes, many orthope...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sprague, Sheila, Bzovsky, Sofia, Connelly, Daniel, Thabane, Lehana, Adachi, Jonathan D., Slobogean, Gerard P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873563/ https://www.ncbi.nlm.nih.gov/pubmed/31768262 http://dx.doi.org/10.1186/s40814-019-0524-4

Ejemplares similares

Fixation using alternative implants for the treatment of hip fractures (FAITH-2): design and rationale for a pilot multi-centre 2 × 2 factorial randomized controlled trial in young femoral neck fracture patients
por: Slobogean, Gerard P., et al.
Publicado: (2019)

Effect of Vitamin D(3) Supplementation on Acute Fracture Healing: A Phase II Screening Randomized Double‐Blind Controlled Trial
por: Slobogean, Gerard P., et al.
Publicado: (2022)

Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures
por: Stewart, Christopher C., et al.
Publicado: (2022)

A pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan
por: O’Hara, Nathan N., et al.
Publicado: (2022)

Patient preferences for nutritional supplementation to improve fracture healing: a discrete choice experiment
por: Nichols, Elizabeth, et al.
Publicado: (2018)

Fixation Using Alternative Implants for the Treatment of Hip Fractures: The feasibility of a multicenter 2 × 2 factorial randomized controlled trial evaluating surgical treatment and vitamin D supplementation in young femoral neck fracture patients
por: Sprague, Sheila, et al.
Publicado: (2020)

Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
por: Li, Guowei, et al.
Publicado: (2013)

Does negative pressure wound therapy reduce the odds of infection and improve health-related quality of life in patients with open fractures?
por: Atwan, Yousif, et al.
Publicado: (2022)

Large variations in the practice patterns of surgical antiseptic preparation solutions in patients with open and closed extremity fractures: a cross-sectional survey
por: Jurado-Ruiz, Maria, et al.
Publicado: (2018)

Association of Patient-Level and Hospital-Level Factors With Timely Fracture Care by Race
por: Gitajn, Ida Leah, et al.
Publicado: (2022)

Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study
por: Sprague, Sheila, et al.
Publicado: (2021)

A Missed Opportunity in Bone Health: Vitamin D and Calcium Use in Elderly Femoral Neck Fracture Patients Following Arthroplasty
por: Sprague, Sheila, et al.
Publicado: (2017)

Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial
por: Busse, Jason W., et al.
Publicado: (2022)

A scoping review of intimate partner violence assistance programmes within health care settings
por: Sprague, Sheila, et al.
Publicado: (2017)

Rationale and Design of Khuzestan Vitamin D Deficiency Screening Program in Pregnancy: A Stratified Randomized Vitamin D Supplementation Controlled Trial
por: Rostami, Maryam, et al.
Publicado: (2017)

Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B(12 )and folic acid on fracture incidence
por: van Wijngaarden, Janneke P, et al.
Publicado: (2011)

An optimized protocol for a standardized, femoral osteotomy model to study fracture healing in mice
por: Jiang, Shan, et al.
Publicado: (2021)

Rationale and methods of an Evaluation of the Effectiveness of the Community Paramedicine at Home (CP@home) program for frequent users of emergency medical services in multiple Ontario regions: a study protocol for a randomized controlled trial
por: Agarwal, Gina, et al.
Publicado: (2019)

Sedentariness and Back Health in Western Cape Primary School Students: Protocol for a Pragmatic Stepped-Wedge Feasibility Randomized Controlled Trial
por: Fisher, Dominic, et al.
Publicado: (2020)

Design and rationale for a pragmatic cluster randomized trial of the Cardiovascular Health Awareness Program (CHAP) for social housing residents in Ontario and Quebec, Canada
por: Agarwal, Gina, et al.
Publicado: (2019)

Prognostic factors for predicting health-related quality of life after intramedullary nailing of tibial fractures: a randomized controlled trial
por: Sprague, Sheila, et al.
Publicado: (2021)

Rationale and design of a randomized controlled trial of the effect of retinol and vitamin D supplementation on treatment in active pulmonary tuberculosis patients with diabetes
por: Wang, Qiuzhen, et al.
Publicado: (2013)

Antibiotic therapy for skin and soft tissue infections: a protocol for a systematic review and network meta-analysis
por: Bartoszko, Jessica J., et al.
Publicado: (2018)

Who, if anyone, may benefit from a total hip arthroplasty after a displaced femoral neck fracture?: a post hoc subgroup analysis of the HEALTH trial
por: Frihagen, Frede, et al.
Publicado: (2022)

Evaluating overweight and obesity prevalence in survivors of childhood brain tumors: a systematic review protocol
por: Wang, Kuan-Wen, et al.
Publicado: (2017)

Association of Three-Month Radiographic Union Score for Tibia Fractures (RUST) with Nonunion in Tibial Shaft Fracture Patients
por: Mundi, Raman, et al.
Publicado: (2020)

Nonunion in Patients with Tibial Shaft Fractures: Is Early Physical Status Associated with Fracture Healing?
por: Mundi, Raman, et al.
Publicado: (2020)

Management of frailty: a protocol of a network meta-analysis of randomized controlled trials
por: Negm, Ahmed M., et al.
Publicado: (2017)

Study Protocol: Effect of Prune on Fracture Healing in Men and Women With a Wrist Fracture
por: Ormsbee, Lauren, et al.
Publicado: (2022)

Male participation in prevention programmes of mother to child transmission of HIV: a protocol for a systematic review to identify barriers, facilitators and reported interventions
por: Morfaw, Frederick LI, et al.
Publicado: (2012)

Factors associated with development of gastrointestinal problems in patients with scleroderma: a protocol for a systematic review
por: Hong, Brian Younho, et al.
Publicado: (2014)

Long-term effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme (a double-blind placebo-controlled study) – rationale for the study design
por: Szlagatys-Sidorkiewicz, Agnieszka, et al.
Publicado: (2017)

Risk Factors Associated With Infection in Open Fractures of the Upper and Lower Extremities
por: Tornetta, Paul, et al.
Publicado: (2020)

Impact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures
por: Swiontkowski, Marc, et al.
Publicado: (2021)

Change in Gustilo-Anderson classification at time of surgery does not increase risk for surgical site infection in patients with open fractures: A secondary analysis of a multicenter, prospective randomized controlled trial
por: Axelrod, Daniel, et al.
Publicado: (2022)

A scoping review of the proximal humerus fracture literature
por: Slobogean, Gerard P, et al.
Publicado: (2015)

Does cumulative topical antibiotic powder use increase the risk of drug induced acute kidney injury in fracture patients?
por: O'Hara, Nathan N., et al.
Publicado: (2022)

Evaluating the effect of delayed activation of rapid response teams on patient outcomes: a systematic review protocol
por: Xu, Michael K., et al.
Publicado: (2018)

Reporting quality of stepped wedge design randomized trials: a systematic review protocol
por: Thabane, Alex, et al.
Publicado: (2016)

Using an Electronic Decision Support Tool to Reduce Inappropriate Polypharmacy and Optimize Medicines: Rationale and Methods
por: Young, Amber, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hceqd6q2h0ute8im66lip7jtg5