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Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved

BACKGROUND: Dexmedetomidine was proved to mitigate bupivacaine-induced cardiotoxicity but mechanism of this ability is still unclear. This study was designed to investigate the direct effects of dexmedetomidine on cardiotoxicity induced by bupivacaine on Langendorff rat heart preparation and the rol...

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Detalles Bibliográficos
Autores principales: Xia, Fangfang, Jin, Zhousheng, Lin, Tingting, Cai, Xixi, Pan, Linmin, Wang, Shi, Cai, Yaoyao, Chen, Hongfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873694/
https://www.ncbi.nlm.nih.gov/pubmed/31753018
http://dx.doi.org/10.1186/s40360-019-0371-1