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Mathematical Approach to Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment

PURPOSE: Drug resistance is a major impediment to the success of cancer treatment. Resistance is typically thought to arise from random genetic mutations, after which mutated cells expand via Darwinian selection. However, recent experimental evidence suggests that progression to drug resistance need...

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Detalles Bibliográficos
Autores principales: Greene, James M., Gevertz, Jana L., Sontag, Eduardo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873992/
https://www.ncbi.nlm.nih.gov/pubmed/30969799
http://dx.doi.org/10.1200/CCI.18.00087