Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway

Chalcone derivatives, as a hot research field, exhibit a variety of physiological bioactivities and target multiple biological receptors. Based on the skeleton of (E)-1,3-diphenyl-2-propene-1-one, 14 chalcone derivatives were designed and synthesized, and evaluated as the antitumor candidates agents...

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Detalles Bibliográficos
Autores principales: Zhu, Hongtian, Tang, Lei, Zhang, Chenghong, Wei, Baochu, Yang, Pingrong, He, Dian, Zheng, Lifang, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874057/
https://www.ncbi.nlm.nih.gov/pubmed/31803052
http://dx.doi.org/10.3389/fphar.2019.01341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874057/
https://www.ncbi.nlm.nih.gov/pubmed/31803052
http://dx.doi.org/10.3389/fphar.2019.01341

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