14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases

The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB)...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Soham, Ylä-Anttila, Päivi, Sandalova, Tatyana, Sun, Renhua, Achour, Adnane, Masucci, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874091/
https://www.ncbi.nlm.nih.gov/pubmed/31710640
http://dx.doi.org/10.1371/journal.ppat.1008146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874091/
https://www.ncbi.nlm.nih.gov/pubmed/31710640
http://dx.doi.org/10.1371/journal.ppat.1008146

Ejemplares similares