Inhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression

PURPOSE: Chordomas are locally aggressive tumors arising from notochordal remnants. Brachyury, a protein coded by T-gene, is crucial for chordoma cell proliferation. The aim of this study was to evaluate the effects of glycogen synthase kinase 3 beta (GSK3β) activity on brachyury expression and on t...

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Detalles Bibliográficos
Autores principales: Yan, Xudong, Li, Zhiyuan, Li, Hong, Liu, Pei, Zhao, Zehang, Cheng, Shan, Wang, Zhenlin, Zhang, Qiuhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874116/
https://www.ncbi.nlm.nih.gov/pubmed/31819479
http://dx.doi.org/10.2147/OTT.S218930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874116/
https://www.ncbi.nlm.nih.gov/pubmed/31819479
http://dx.doi.org/10.2147/OTT.S218930

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