Incorporating NTCP into Randomized Trials of Proton Versus Photon Therapy

PURPOSE: We propose and simulate a model-based methodology to incorporate heterogeneous treatment benefit of proton therapy (PrT) versus photon therapy into randomized trial designs. We use radiation-induced pneumonitis (RP) as an exemplar. The aim is to obtain an unbiased estimate of how predicted...

Descripción completa

Detalles Bibliográficos
Autores principales: Scherman, Jonas, Appelt, Ane L., Yu, Jen, Persson, Gitte Fredberg, Nygård, Lotte, Langendijk, Johannes A., Bentzen, Søren M., Vogelius, Ivan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Particle Therapy Co-operative Group 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874185/
https://www.ncbi.nlm.nih.gov/pubmed/31788505
http://dx.doi.org/10.14338/IJPT-18-00038.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874185/
https://www.ncbi.nlm.nih.gov/pubmed/31788505
http://dx.doi.org/10.14338/IJPT-18-00038.1

Ejemplares similares