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Incorporating NTCP into Randomized Trials of Proton Versus Photon Therapy
PURPOSE: We propose and simulate a model-based methodology to incorporate heterogeneous treatment benefit of proton therapy (PrT) versus photon therapy into randomized trial designs. We use radiation-induced pneumonitis (RP) as an exemplar. The aim is to obtain an unbiased estimate of how predicted...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Particle Therapy Co-operative Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874185/ https://www.ncbi.nlm.nih.gov/pubmed/31788505 http://dx.doi.org/10.14338/IJPT-18-00038.1 |