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Incorporating NTCP into Randomized Trials of Proton Versus Photon Therapy

PURPOSE: We propose and simulate a model-based methodology to incorporate heterogeneous treatment benefit of proton therapy (PrT) versus photon therapy into randomized trial designs. We use radiation-induced pneumonitis (RP) as an exemplar. The aim is to obtain an unbiased estimate of how predicted...

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Detalles Bibliográficos
Autores principales:	Scherman, Jonas, Appelt, Ane L., Yu, Jen, Persson, Gitte Fredberg, Nygård, Lotte, Langendijk, Johannes A., Bentzen, Søren M., Vogelius, Ivan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Particle Therapy Co-operative Group 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874185/ https://www.ncbi.nlm.nih.gov/pubmed/31788505 http://dx.doi.org/10.14338/IJPT-18-00038.1

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