Age-associated changes in human CD4(+) T cells point to mitochondrial dysfunction consequent to impaired autophagy

To gain understanding on the mechanisms that drive immunosenescence in humans, we examined CD4(+) T cells obtained from younger (20-39 years-old) and older (70+ years-old) healthy participants of the Baltimore Longitudinal Study on Aging (BLSA). We found that mitochondrial proteins involved in the e...

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Detalles Bibliográficos
Autores principales: Bektas, Arsun, Schurman, Shepherd H., Gonzalez-Freire, Marta, Dunn, Christopher A., Singh, Amit K., Macian, Fernando, Cuervo, Ana Maria, Sen, Ranjan, Ferrucci, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874450/
https://www.ncbi.nlm.nih.gov/pubmed/31707363
http://dx.doi.org/10.18632/aging.102438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874450/
https://www.ncbi.nlm.nih.gov/pubmed/31707363
http://dx.doi.org/10.18632/aging.102438

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