Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults

Histone deacetylase (HDAC) enzymes are targets for the development of antimalarial drugs with a different mode of action to established antimalarials. Broad-spectrum HDAC-inhibitors show high potency against Plasmodium falciparum, but displayed some toxicity towards human cells. Inhibitors of human...

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Detalles Bibliográficos
Autores principales: Koehne, Erik, Kreidenweiss, Andrea, Zoleko Manego, Rella, McCall, Matthew, Mombo-Ngoma, Ghyslain, Mackwitz, Marcel Karl Walter, Hansen, Finn K., Held, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874535/
https://www.ncbi.nlm.nih.gov/pubmed/31758015
http://dx.doi.org/10.1038/s41598-019-53912-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874535/
https://www.ncbi.nlm.nih.gov/pubmed/31758015
http://dx.doi.org/10.1038/s41598-019-53912-w

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