Cargando…

New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers

Oligomers of intracellular amyloid β protein (Aβ) are strongly cytotoxic and play crucial roles in synaptic transmission and cognitive function in Alzheimer’s disease (AD). However, there is currently no AD model mouse in which to specifically analyze the function of Aβ oligomers only. We have now d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ochiishi, Tomoyo, Kaku, Masami, Kiyosue, Kazuyuki, Doi, Motomichi, Urabe, Takao, Hattori, Nobutaka, Shimura, Hideki, Ebihara, Tatsuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874556/ https://www.ncbi.nlm.nih.gov/pubmed/31757975 http://dx.doi.org/10.1038/s41598-019-53415-8

Ejemplares similares

Development of new fusion proteins for visualizing amyloid-β oligomers in vivo
por: Ochiishi, Tomoyo, et al.
Publicado: (2016)

Art and Parkinson’s disease: a dramatic change in an artist’s style as an initial symptom
por: Shimura, Hideki, et al.
Publicado: (2011)

Widespread enlarged perivascular spaces associated with dementia and focal brain dysfunction: case report
por: Taniguchi, Daisuke, et al.
Publicado: (2017)

Rivastigmine improves dual-task gait velocity in patients with Alzheimer’s disease
por: Shimura, Hideki, et al.
Publicado: (2021)

Glycyl-alanyl-histidine protects PC12 cells against hydrogen peroxide toxicity
por: Shimura, Hideki, et al.
Publicado: (2017)

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta
por: Hilt, Silvia, et al.
Publicado: (2018)

Acute transient freezing of gait in a patient with posterior reversible encephalopathy syndrome
por: Nakajima, Asuka, et al.
Publicado: (2013)

Marchiafava-Bignami disease mimics motor neuron disease: case report
por: Hoshino, Yasunobu, et al.
Publicado: (2013)

Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes
por: Brewer, Gregory J., et al.
Publicado: (2020)

Human-Derived Physiological Heat Shock Protein 27 Complex Protects Brain after Focal Cerebral Ischemia in Mice
por: Teramoto, Shinichiro, et al.
Publicado: (2013)

Cerebral Microbleeds Are Associated with Worse Cognitive Function in the Nondemented Elderly with Small Vessel Disease
por: Yamashiro, Kazuo, et al.
Publicado: (2014)

Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator
por: Shimada, Yoshiaki, et al.
Publicado: (2018)

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
por: Suelves, Nuria, et al.
Publicado: (2023)

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture
por: Skovronsky, Daniel M., et al.
Publicado: (1998)

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain
por: Welikovitch, Lindsay A., et al.
Publicado: (2020)

Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain
por: Li, Hailong, et al.
Publicado: (2022)

Convulsive Movements in Bilateral Paramedian Thalamic and Midbrain Infarction
por: Yamashiro, Kazuo, et al.
Publicado: (2011)

Selective Aptamer‐Based Control of Intraneuronal Signaling
por: Lennarz, Sabine, et al.
Publicado: (2015)

Longitudinally Extensive Transverse Myelitis with Intramedullary Metastasis of Small-Cell Lung Carcinoma: An Autopsy Case Report
por: Nishioka, Kenya, et al.
Publicado: (2013)

Multiple cerebral infarction diagnosed as Eosinophilic Granulomatosis with Polyangiitis by autopsy
por: Hira, Kenichiro, et al.
Publicado: (2019)

Impact of D-dimer for pathologic differentiation on transesophageal echocardiography in embolic stroke of undetermined source: a single-center experience
por: Hira, Kenichiro, et al.
Publicado: (2022)

Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein
por: Kaur, Gurjinder, et al.
Publicado: (2016)

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy
por: Saito, Satoshi, et al.
Publicado: (2017)

Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses
por: Takahashi, Reisuke H., et al.
Publicado: (2013)

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific
por: Dafnis, Ioannis, et al.
Publicado: (2016)

The Toxicity of Amyloid β Oligomers
por: Zhao, Li Na, et al.
Publicado: (2012)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
por: Sosna, Justyna, et al.
Publicado: (2018)

Influenza-associated MOG antibody-positive longitudinally extensive transverse myelitis: a case report
por: Amano, Haruka, et al.
Publicado: (2014)

Intraneuronal accumulation of amyloid-β peptides as the pathomechanism linking autism and its co-morbidities: epilepsy and self-injurious behavior — the hypothesis
por: Frackowiak, Janusz, et al.
Publicado: (2023)

Synapses, Synaptic Activity and Intraneuronal Aβ in Alzheimer's Disease
por: Tampellini, Davide, et al.
Publicado: (2010)

Intraneuronal tau aggregation induces the integrated stress response in astrocytes
por: Batenburg, Kevin L, et al.
Publicado: (2022)

Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity
por: Kalinichenko, Andrei L., et al.
Publicado: (2023)

Immunogenic properties of amyloid beta oligomers
por: Dalgediene, Indre, et al.
Publicado: (2013)

Breaking the Code of Amyloid-β Oligomers
por: Lesné, Sylvain E.
Publicado: (2013)

The Toxicity and Polymorphism of β-Amyloid Oligomers
por: Huang, Ya-ru, et al.
Publicado: (2020)

Single Molecule Characterization of Amyloid Oligomers
por: Yang, Jie, et al.
Publicado: (2021)

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype
por: Christensen, Ditte Z., et al.
Publicado: (2010)

Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer's Disease
por: Van Dooren, Tom, et al.
Publicado: (2014)

Arrestin-mediated desensitization enables intraneuronal olfactory discrimination in Caenorhabditis elegans
por: Merritt, Daniel M., et al.
Publicado: (2022)

Amyloid-Beta 1-42 Cross-Reactive Antibody Prevalent in Human Sera May Contribute to Intraneuronal Deposition of A-Beta-P-42
por: Vojdani, Aristo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sbvhpnncrd62ntv1v2sploblqe