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The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH
The polymeric mucin MUC5B provides the structural and functional framework of respiratory mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective barrier. Whilst it is established that MUC5B forms disulfide-linked linear polymers, how this relates to their packagi...
Autores principales: | Hughes, Gareth W., Ridley, Caroline, Collins, Richard, Roseman, Alan, Ford, Robert, Thornton, David J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874590/ https://www.ncbi.nlm.nih.gov/pubmed/31758042 http://dx.doi.org/10.1038/s41598-019-53768-0 |
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