Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout

Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident molecular chaperone that specifically recognizes triple helical portions of procollagens. The chaperone function of HSP47 is indispensable in mammals, and hsp47-null mice show an embryonic lethal phenotype accompanied by severe...

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Detalles Bibliográficos
Autores principales: Fujii, Kazunori K., Taga, Yuki, Sakai, Takayuki, Ito, Shinya, Hattori, Shunji, Nagata, Kazuhiro, Koide, Takaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874656/
https://www.ncbi.nlm.nih.gov/pubmed/31758055
http://dx.doi.org/10.1038/s41598-019-53962-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874656/
https://www.ncbi.nlm.nih.gov/pubmed/31758055
http://dx.doi.org/10.1038/s41598-019-53962-0

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