Cargando…

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease

Alpha-synuclein (aSyn) is the main component of Lewy bodies, the histopathological marker in Parkinson’s disease (PD), and point mutations and multiplications of the aSyn coding SNCA gene correlate with early onset PD. Therefore, various transgenic mouse models overexpressing native or point-mutated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kilpeläinen, Tommi, Julku, Ulrika H., Svarcbahs, Reinis, Myöhänen, Timo T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874660/ https://www.ncbi.nlm.nih.gov/pubmed/31758049 http://dx.doi.org/10.1038/s41598-019-54034-z

Ejemplares similares

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo
por: Svarcbahs, Reinis, et al.
Publicado: (2018)

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner
por: Julku, Ulrika H., et al.
Publicado: (2021)

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson’s Disease
por: Kilpeläinen, Tommi P., et al.
Publicado: (2023)

Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy
por: Cui, Hengjing, et al.
Publicado: (2021)

TDP-43 Potentiates Alpha-synuclein Toxicity to Dopaminergic Neurons in Transgenic Mice
por: Tian, Tian, et al.
Publicado: (2011)

Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function
por: Oaks, Adam W., et al.
Publicado: (2013)

Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice
por: Liu, Yan, et al.
Publicado: (2014)

High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein
por: Jia, Fengju, et al.
Publicado: (2018)

Ethanol extract from Gynostemma pentaphyllum ameliorates dopaminergic neuronal cell death in transgenic mice expressing mutant A53T human alpha-synuclein
por: Park, Hyun Jin, et al.
Publicado: (2019)

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease
por: Minakaki, Georgia, et al.
Publicado: (2020)

Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology
por: Ra, Eun A., et al.
Publicado: (2023)

Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease
por: Lelan, Faustine, et al.
Publicado: (2011)

Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice
por: Lee, He-Jin, et al.
Publicado: (2011)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian
por: Mo, Mingshu, et al.
Publicado: (2016)

IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models
por: Arcos, Javiera, et al.
Publicado: (2023)

Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice
por: Chen, Xi, et al.
Publicado: (2015)

The Role of Alpha-Synuclein in Melanin Synthesis in Melanoma and Dopaminergic Neuronal Cells
por: Pan, Tianhong, et al.
Publicado: (2012)

In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis
por: Ouzounoglou, Eleftherios, et al.
Publicado: (2014)

Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence
por: Henriques, Alexandre, et al.
Publicado: (2022)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Alpha-synuclein spreading in Parkinson’s disease
por: Recasens, Ariadna, et al.
Publicado: (2014)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease
por: Sossi, Vesna, et al.
Publicado: (2022)

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson’s Model
por: Lai, Jessica IChi, et al.
Publicado: (2023)

Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice
por: Mendritzki, Sonja, et al.
Publicado: (2010)

Dimebon Does Not Ameliorate Pathological Changes Caused by Expression of Truncated (1–120) Human Alpha-Synuclein in Dopaminergic Neurons of Transgenic Mice
por: Shelkovnikova, Tatyana A., et al.
Publicado: (2011)

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease
por: Chen, Qian-Qian, et al.
Publicado: (2018)

Ischemic stroke causes Parkinson’s disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein
por: Lohmann, Stephanie, et al.
Publicado: (2022)

No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models
por: Sastry, Namratha, et al.
Publicado: (2015)

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
por: Angot, Elodie, et al.
Publicado: (2012)

Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons
por: Tai, Yunchun, et al.
Publicado: (2014)

Hypoxic stress accelerates the propagation of pathological alpha‐synuclein and degeneration of dopaminergic neurons
por: Guo, Mengyuan, et al.
Publicado: (2022)

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
por: Gómez-Benito, Mónica, et al.
Publicado: (2020)

Alpha-Synuclein and Cognitive Decline in Parkinson Disease
por: Fan, Tian-Sin, et al.
Publicado: (2021)

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype
por: Faustini, Gaia, et al.
Publicado: (2022)

Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
por: Cao, Pengxiu, et al.
Publicado: (2010)

Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells
por: Chau, K.Y., et al.
Publicado: (2010)

Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway
por: Kim, Ji-Young, et al.
Publicado: (2013)

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice
por: Cai, Waijiao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2107dadd5bfkliuvqaafi46s9c