In Utero Exposure to Gestational Diabetes Alters DNA Methylation and Gene Expression of CDKN2A/B in Langerhans Islets of Rat Offspring

OBJECTIVE: DNA methylation, a major epigenetic reprogramming mechanism, contributes to the increased prevalence of type 2 diabetes mellitus (T2DM). Based on genome-wide association studies, polymorphisms in CDKN2A/B are associated with T2DM. Our previous studies showed that gestational diabetes mell...

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Detalles Bibliográficos
Autores principales: Nazari, Zahra, Shahryari, Alireza, Ghafari, Soraya, Nabiuni, Mohammad, Golalipour, Mohammad Jafar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874789/
https://www.ncbi.nlm.nih.gov/pubmed/31721535
http://dx.doi.org/10.22074/cellj.2020.6699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874789/
https://www.ncbi.nlm.nih.gov/pubmed/31721535
http://dx.doi.org/10.22074/cellj.2020.6699

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