Cargando…
Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. RS could reduce blood glucose and ameliorate IR in animals, but its effect in human population is co...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875042/ https://www.ncbi.nlm.nih.gov/pubmed/31760943 http://dx.doi.org/10.1186/s12944-019-1127-z |
_version_ | 1783472941931954176 |
---|---|
author | Gao, Chenlin Rao, Mingyue Huang, Wei Wan, Qin Yan, Pijun Long, Yang Guo, Man Xu, Youhua Xu, Yong |
author_facet | Gao, Chenlin Rao, Mingyue Huang, Wei Wan, Qin Yan, Pijun Long, Yang Guo, Man Xu, Youhua Xu, Yong |
author_sort | Gao, Chenlin |
collection | PubMed |
description | BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. RS could reduce blood glucose and ameliorate IR in animals, but its effect in human population is controversial. OBJECTIVE: The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity. METHODS: Databases that supplemented with RS in ameliorating IR in T2DM and simple obesity were queried for studies on or before August 15, 2018. Parameters including fasting insulin, fasting glucose, body mass index (BMI), homeostatic model assessment (HOMA) etc. were extracted from studies to systemically evaluate effects of RS. RESULTS: The database search yielded 14 parallel or crossover studies that met the inclusion criteria. The results indicated that there was no significant difference in the amelioration of BMI, HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation. However, the fasting blood glucose, fasting insulin and HOMA-IR in T2DM with obesity who supplemented RS were lower than control group, and the subgroup analysis according to the dose of RS supplementation was inconsistency. There was no significant difference between RS and non-RS supplements in patients with simple obesity. CONCLUSION: RS supplementation can ameliorate IR in T2DM, especially for the patients of T2DM with obesity, but not in simple obesity. |
format | Online Article Text |
id | pubmed-6875042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68750422019-11-29 Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis Gao, Chenlin Rao, Mingyue Huang, Wei Wan, Qin Yan, Pijun Long, Yang Guo, Man Xu, Youhua Xu, Yong Lipids Health Dis Research BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. RS could reduce blood glucose and ameliorate IR in animals, but its effect in human population is controversial. OBJECTIVE: The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity. METHODS: Databases that supplemented with RS in ameliorating IR in T2DM and simple obesity were queried for studies on or before August 15, 2018. Parameters including fasting insulin, fasting glucose, body mass index (BMI), homeostatic model assessment (HOMA) etc. were extracted from studies to systemically evaluate effects of RS. RESULTS: The database search yielded 14 parallel or crossover studies that met the inclusion criteria. The results indicated that there was no significant difference in the amelioration of BMI, HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation. However, the fasting blood glucose, fasting insulin and HOMA-IR in T2DM with obesity who supplemented RS were lower than control group, and the subgroup analysis according to the dose of RS supplementation was inconsistency. There was no significant difference between RS and non-RS supplements in patients with simple obesity. CONCLUSION: RS supplementation can ameliorate IR in T2DM, especially for the patients of T2DM with obesity, but not in simple obesity. BioMed Central 2019-11-24 /pmc/articles/PMC6875042/ /pubmed/31760943 http://dx.doi.org/10.1186/s12944-019-1127-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Gao, Chenlin Rao, Mingyue Huang, Wei Wan, Qin Yan, Pijun Long, Yang Guo, Man Xu, Youhua Xu, Yong Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
title | Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
title_full | Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
title_fullStr | Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
title_full_unstemmed | Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
title_short | Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
title_sort | resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875042/ https://www.ncbi.nlm.nih.gov/pubmed/31760943 http://dx.doi.org/10.1186/s12944-019-1127-z |
work_keys_str_mv | AT gaochenlin resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT raomingyue resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT huangwei resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT wanqin resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT yanpijun resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT longyang resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT guoman resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT xuyouhua resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis AT xuyong resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis |