Cargando…

Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis

BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. RS could reduce blood glucose and ameliorate IR in animals, but its effect in human population is co...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Chenlin, Rao, Mingyue, Huang, Wei, Wan, Qin, Yan, Pijun, Long, Yang, Guo, Man, Xu, Youhua, Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875042/
https://www.ncbi.nlm.nih.gov/pubmed/31760943
http://dx.doi.org/10.1186/s12944-019-1127-z
_version_ 1783472941931954176
author Gao, Chenlin
Rao, Mingyue
Huang, Wei
Wan, Qin
Yan, Pijun
Long, Yang
Guo, Man
Xu, Youhua
Xu, Yong
author_facet Gao, Chenlin
Rao, Mingyue
Huang, Wei
Wan, Qin
Yan, Pijun
Long, Yang
Guo, Man
Xu, Youhua
Xu, Yong
author_sort Gao, Chenlin
collection PubMed
description BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. RS could reduce blood glucose and ameliorate IR in animals, but its effect in human population is controversial. OBJECTIVE: The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity. METHODS: Databases that supplemented with RS in ameliorating IR in T2DM and simple obesity were queried for studies on or before August 15, 2018. Parameters including fasting insulin, fasting glucose, body mass index (BMI), homeostatic model assessment (HOMA) etc. were extracted from studies to systemically evaluate effects of RS. RESULTS: The database search yielded 14 parallel or crossover studies that met the inclusion criteria. The results indicated that there was no significant difference in the amelioration of BMI, HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation. However, the fasting blood glucose, fasting insulin and HOMA-IR in T2DM with obesity who supplemented RS were lower than control group, and the subgroup analysis according to the dose of RS supplementation was inconsistency. There was no significant difference between RS and non-RS supplements in patients with simple obesity. CONCLUSION: RS supplementation can ameliorate IR in T2DM, especially for the patients of T2DM with obesity, but not in simple obesity.
format Online
Article
Text
id pubmed-6875042
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-68750422019-11-29 Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis Gao, Chenlin Rao, Mingyue Huang, Wei Wan, Qin Yan, Pijun Long, Yang Guo, Man Xu, Youhua Xu, Yong Lipids Health Dis Research BACKGROUND: Resistant starch (RS) is a starch that can be fermented by the microbial flora within gut lumen. Insulin resistance (IR) is a pathophysiological condition related to diabetes and obesity. RS could reduce blood glucose and ameliorate IR in animals, but its effect in human population is controversial. OBJECTIVE: The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity. METHODS: Databases that supplemented with RS in ameliorating IR in T2DM and simple obesity were queried for studies on or before August 15, 2018. Parameters including fasting insulin, fasting glucose, body mass index (BMI), homeostatic model assessment (HOMA) etc. were extracted from studies to systemically evaluate effects of RS. RESULTS: The database search yielded 14 parallel or crossover studies that met the inclusion criteria. The results indicated that there was no significant difference in the amelioration of BMI, HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation. However, the fasting blood glucose, fasting insulin and HOMA-IR in T2DM with obesity who supplemented RS were lower than control group, and the subgroup analysis according to the dose of RS supplementation was inconsistency. There was no significant difference between RS and non-RS supplements in patients with simple obesity. CONCLUSION: RS supplementation can ameliorate IR in T2DM, especially for the patients of T2DM with obesity, but not in simple obesity. BioMed Central 2019-11-24 /pmc/articles/PMC6875042/ /pubmed/31760943 http://dx.doi.org/10.1186/s12944-019-1127-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Gao, Chenlin
Rao, Mingyue
Huang, Wei
Wan, Qin
Yan, Pijun
Long, Yang
Guo, Man
Xu, Youhua
Xu, Yong
Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
title Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
title_full Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
title_fullStr Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
title_full_unstemmed Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
title_short Resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
title_sort resistant starch ameliorated insulin resistant in patients of type 2 diabetes with obesity: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875042/
https://www.ncbi.nlm.nih.gov/pubmed/31760943
http://dx.doi.org/10.1186/s12944-019-1127-z
work_keys_str_mv AT gaochenlin resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT raomingyue resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT huangwei resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT wanqin resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT yanpijun resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT longyang resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT guoman resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT xuyouhua resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis
AT xuyong resistantstarchamelioratedinsulinresistantinpatientsoftype2diabeteswithobesityasystematicreviewandmetaanalysis