Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes

Chronic exposure to arsenic induces a variety of cancers, particularly in the skin. Autophagy is a highly conserved process which plays a dual role in tumorigenesis. In the present study, we found that chronic exposure to an environmentally relevant dose of arsenite induced malignant transformation...

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Detalles Bibliográficos
Autores principales: Wu, Xiafang, Sun, Ru, Wang, Huihui, Yang, Bei, Wang, Fang, Xu, Hongtao, Chen, Shimin, Zhao, Rui, Pi, Jingbo, Xu, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875345/
https://www.ncbi.nlm.nih.gov/pubmed/31781319
http://dx.doi.org/10.1155/2019/1038932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875345/
https://www.ncbi.nlm.nih.gov/pubmed/31781319
http://dx.doi.org/10.1155/2019/1038932

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