4-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress in Chondrocytes That Is Caused by Loss of the Protein Disulfide Isomerase ERp57

OBJECTIVE: The integrity of cartilage depends on the correct synthesis of extracellular matrix (ECM) components. In case of insufficient folding of proteins in the endoplasmic reticulum (ER) of chondrocytes, ECM proteins aggregate, ER stress evolves, and the unfolded protein response (UPR) is initia...

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Detalles Bibliográficos
Autores principales: Rellmann, Yvonne, Gronau, Isabel, Hansen, Uwe, Dreier, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875354/
https://www.ncbi.nlm.nih.gov/pubmed/31781343
http://dx.doi.org/10.1155/2019/6404035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875354/
https://www.ncbi.nlm.nih.gov/pubmed/31781343
http://dx.doi.org/10.1155/2019/6404035

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