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Treatment with Methotrexate and Intravenous Cyclophosphamide Pulse Therapy Regulates the P-gp(+)CD4(+) Cell-related Pathogenesis in a Representative Patient with Refractory Proliferative Lupus Nephritis
Diffuse proliferative lupus nephritis (DPLN) is a serious organ complication. Drug resistance correlates with P-glycoprotein (P-gp) expression on activated lymphocytes. We encountered a refractory DPLN patient with expansion of peripheral CD69/CXCR3-co-expressing P-gp(+)CD4(+) cells producing IL-2 a...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japanese Society of Internal Medicine
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875445/ https://www.ncbi.nlm.nih.gov/pubmed/31685786 http://dx.doi.org/10.2169/internalmedicine.2589-18 |