Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

Haematological toxicity associated with cancer therapeutics is monitored by changes in blood cell count, and their primary effect is on proliferative progenitors in the bone marrow. Using observations in rat bone marrow and blood, we characterize a mathematical model that comprises cell proliferatio...

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Detalles Bibliográficos
Autores principales: Fornari, Chiara, Oplustil O'Connor, Lenka, Pin, Carmen, Smith, Aaron, Yates, James W.T., Cheung, S.Y. Amy, Jodrell, Duncan I., Mettetal, Jerome T., Collins, Teresa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875710/
https://www.ncbi.nlm.nih.gov/pubmed/31508894
http://dx.doi.org/10.1002/psp4.12459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875710/
https://www.ncbi.nlm.nih.gov/pubmed/31508894
http://dx.doi.org/10.1002/psp4.12459

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