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Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis

The activation of innate immune receptors by pathogen-associated molecular patterns (PAMPs) is central to host defense against infections. On the other hand, these receptors are also activated by immunogenic damage-associated molecular patterns (DAMPs), typically released from dying cells, and the a...

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Detalles Bibliográficos
Autores principales: Negishi, Hideo, Endo, Nobuyasu, Nakajima, Yuki, Nishiyama, Tatsuaki, Tabunoki, Yuichiro, Nishio, Junko, Koshiba, Ryuji, Matsuda, Atsushi, Matsuki, Kosuke, Okamura, Tomohisa, Negishi-Koga, Takako, Ichinohe, Takeshi, Takemura, Shunji, Ishiwata, Hiroyuki, Iemura, Shun-ichiro, Natsume, Tohru, Abe, Takaya, Kiyonari, Hiroshi, Doi, Takeshi, Hangai, Sho, Yanai, Hideyuki, Fujio, Keishi, Yamamoto, Kazuhiko, Taniguchi, Tadatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876158/
https://www.ncbi.nlm.nih.gov/pubmed/31694883
http://dx.doi.org/10.1073/pnas.1915326116