Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

The early stages of age-related macular degeneration (AMD) are characterized by the accumulation of basal laminar deposits (BLamDs). The mechanism for BLamDs accumulating between the retinal pigment epithelium (RPE) and its basal lamina remains elusive. Here we examined the role in AMD of lysosome-a...

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Detalles Bibliográficos
Autores principales: Notomi, Shoji, Ishihara, Kenji, Efstathiou, Nikolaos E., Lee, Jong-Jer, Hisatomi, Toshio, Tachibana, Takashi, Konstantinou, Eleni K., Ueta, Takashi, Murakami, Yusuke, Maidana, Daniel E., Ikeda, Yasuhiro, Kume, Shinji, Terasaki, Hiroto, Sonoda, Shozo, Blanz, Judith, Young, Lucy, Sakamoto, Taiji, Sonoda, Koh-Hei, Saftig, Paul, Ishibashi, Tatsuro, Miller, Joan W., Kroemer, Guido, Vavvas, Demetrios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876195/
https://www.ncbi.nlm.nih.gov/pubmed/31699817
http://dx.doi.org/10.1073/pnas.1906643116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876195/
https://www.ncbi.nlm.nih.gov/pubmed/31699817
http://dx.doi.org/10.1073/pnas.1906643116

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