POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length

Telomeres cap the ends of linear chromosomes and terminate in a single-stranded DNA (ssDNA) overhang recognized by POT1-TPP1 heterodimers to help regulate telomere length homeostasis. Here hydroxyl radical footprinting coupled with mass spectrometry was employed to probe protein–protein interactions...

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Detalles Bibliográficos
Autores principales: Xu, Mengyuan, Kiselar, Janna, Whited, Tawna L., Hernandez-Sanchez, Wilnelly, Taylor, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876245/
https://www.ncbi.nlm.nih.gov/pubmed/31685617
http://dx.doi.org/10.1073/pnas.1905381116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876245/
https://www.ncbi.nlm.nih.gov/pubmed/31685617
http://dx.doi.org/10.1073/pnas.1905381116

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