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SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization

Sonic hedgehog (SHH) signaling plays a pivotal role in 2 different phases during brain development. Early SHH signaling derived from the prechordal plate (PrCP) triggers secondary Shh induction in the forebrain, which overlies the PrCP, and the induced SHH signaling, in turn, directs late neuronal d...

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Detalles Bibliográficos
Autores principales: Sagai, Tomoko, Amano, Takanori, Maeno, Akiteru, Ajima, Rieko, Shiroishi, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876251/
https://www.ncbi.nlm.nih.gov/pubmed/31685615
http://dx.doi.org/10.1073/pnas.1901732116