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Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia

During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes. A corresponding mutant line was established and referred to as Aey69 (abnormality of the eye #69). Comprehensive phenotyping of the homozygous Aey69 mutants in the German...

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Detalles Bibliográficos
Autores principales: Vetrivel, Sharmilee, Tiso, Natascia, Kügler, Andrea, Irmler, Martin, Horsch, Marion, Beckers, Johannes, Hladik, Daniela, Giesert, Florian, Gailus-Durner, Valerie, Fuchs, Helmut, Sabrautzki, Sibylle, Hrabě de Angelis, Martin, Graw, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876282/
https://www.ncbi.nlm.nih.gov/pubmed/30991053
http://dx.doi.org/10.1016/j.exer.2019.03.024