Cargando…
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
DNA replication stress-mediated activation of the ATR kinase pathway is important for maintaining genomic stability. In this study, we identified a zinc finger protein, ZFP161 that functions as a replication stress response factor in ATR activation. Mechanistically, ZFP161 acts as a scaffolding prot...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876566/ https://www.ncbi.nlm.nih.gov/pubmed/31757956 http://dx.doi.org/10.1038/s41467-019-13321-z |