Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria

Aztreonam‐avibactam (ATM‐AVI) is a promising combination to treat serious infections caused by multidrug‐resistant (MDR) pathogens. Three distinct mechanisms of action have been previously characterized for AVI: inhibition of ATM degradation by β‐lactamases, proper bactericidal effect, and enhanceme...

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Detalles Bibliográficos
Autores principales: Chauzy, Alexia, Gaelzer Silva Torres, Bruna, Buyck, Julien, de Jonge, Boudewijn, Adier, Christophe, Marchand, Sandrine, Couet, William, Grégoire, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876579/
https://www.ncbi.nlm.nih.gov/pubmed/31420947
http://dx.doi.org/10.1002/psp4.12452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876579/
https://www.ncbi.nlm.nih.gov/pubmed/31420947
http://dx.doi.org/10.1002/psp4.12452

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