Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is unknown. Here we demonstrate that intestine-specific deletion of Hdac3 (Hdac3(IKO)) protects mice from diet induced ob...

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Detalles Bibliográficos
Autores principales: Dávalos-Salas, Mercedes, Montgomery, Magdalene K., Reehorst, Camilla M., Nightingale, Rebecca, Ng, Irvin, Anderton, Holly, Al-Obaidi, Sheren, Lesmana, Analia, Scott, Cameron M., Ioannidis, Paul, Kalra, Hina, Keerthikumar, Shivakumar, Tögel, Lars, Rigopoulos, Angela, Gong, Sylvia J., Williams, David S., Yoganantharaja, Prusoth, Bell-Anderson, Kim, Mathivanan, Suresh, Gibert, Yann, Hiebert, Scott, Scott, Andrew M., Watt, Matthew J., Mariadason, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876593/
https://www.ncbi.nlm.nih.gov/pubmed/31757939
http://dx.doi.org/10.1038/s41467-019-13180-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876593/
https://www.ncbi.nlm.nih.gov/pubmed/31757939
http://dx.doi.org/10.1038/s41467-019-13180-8

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