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Quantifying pluripotency landscape of cell differentiation from scRNA-seq data by continuous birth-death process

Modeling cell differentiation from omics data is an essential problem in systems biology research. Although many algorithms have been established to analyze scRNA-seq data, approaches to infer the pseudo-time of cells or quantify their potency have not yet been satisfactorily solved. Here, we propos...

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Detalles Bibliográficos
Autores principales: Shi, Jifan, Li, Tiejun, Chen, Luonan, Aihara, Kazuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876891/
https://www.ncbi.nlm.nih.gov/pubmed/31721764
http://dx.doi.org/10.1371/journal.pcbi.1007488