Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of local anesthetic sodium channel blockers like QX-314...

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Detalles Bibliográficos
Autores principales: Lee, Seungkyu, Jo, Sooyeon, Talbot, Sébastien, Zhang, Han-Xiong Bear, Kotoda, Masakazu, Andrews, Nick A, Puopolo, Michelino, Liu, Pin W, Jacquemont, Thomas, Pascal, Maud, Heckman, Laurel M, Jain, Aakanksha, Lee, Jinbo, Woolf, Clifford J, Bean, Bruce P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877086/
https://www.ncbi.nlm.nih.gov/pubmed/31765298
http://dx.doi.org/10.7554/eLife.48118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877086/
https://www.ncbi.nlm.nih.gov/pubmed/31765298
http://dx.doi.org/10.7554/eLife.48118

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