A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth

NV669 is an aminosterol derived from squalamine found to possess strong anticancer effects. The aim of this study was to investigate NV669’s beneficial effects on human pancreatic and hepatic cancer models and to decipher the cellular and molecular mechanisms involved in tumor growth decrease upon t...

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Detalles Bibliográficos
Autores principales: Carmona, Sylvie, Brunel, Jean-Michel, Bonier, Rénaté, Sbarra, Véronique, Robert, Stéphane, Borentain, Patrick, Lombardo, Dominique, Mas, Eric, Gerolami, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877102/
https://www.ncbi.nlm.nih.gov/pubmed/31803360
http://dx.doi.org/10.18632/oncotarget.27286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877102/
https://www.ncbi.nlm.nih.gov/pubmed/31803360
http://dx.doi.org/10.18632/oncotarget.27286

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