Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models

The alkylating agent platinum is first-line chemotherapy treatment for high-grade serous carcinomas (HGSC) of tubal-ovarian origin. Platinum compounds cause DNA damage and induce apoptotic cell death in the bulk tumor population. However, subpopulations of tumor cells may exhibit diverging behaviors...

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Detalles Bibliográficos
Autores principales: Yeung, Tony, Fung, Oliver, Bashkurov, Mikhail, Khandani, Arian, Subedar, Omar, Wudwud, Alexandra, Shaw, Patricia, Clarke, Blaise, Bartlett, John, Rottapel, Robert, Kapus, Andras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877103/
https://www.ncbi.nlm.nih.gov/pubmed/31803363
http://dx.doi.org/10.18632/oncotarget.27330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877103/
https://www.ncbi.nlm.nih.gov/pubmed/31803363
http://dx.doi.org/10.18632/oncotarget.27330

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